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Because the thyroid hormones regulate the turnover of bone cells, an excess of these hormones can shorten the bone-remodeling cycle

Differential methylation in ID-associated genes (e.g., COLEC11 , SHANK2 , GLI2 , and KCNQ2 ) and imprinted genes (e.g., FAM50B and MEG3 ) suggests that some ID patients may have undiagnosed imprinting disorders (Kolarova et al., 2015)

The crack should appear consistently raised from one end to the other

Observations on the spinal dorsal horn revealed suppression of the NF-B pathway, decreased activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), decreased TNF-, and increased IL-10

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Moreover, pharmacokinetic constraints-including limited bioavailability and uncertain brain penetration-must be considered when interpreting gene-expression effects observed in vitro